Cleveland Guardians vs. Chicago White Sox 2025 home opener guide: What’s new at Progressive Field? April 3, 2025 by WKYC Cleveland Guardians will face the Chicago White Sox in the 2025 home opener at Progressive Field on April 8. First pitch is set for 4:10 p.m. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)